Teaching Experience

CURRENT     Assistant Professor of Biochemistry, St. Mary’s College of Maryland

8/10-5/11        Adjunct Faculty, Penn State Abington

Chemistry for Non-Science Majors (Fall 2010)

Organic Chemistry Laboratory (Spring 2011)

8/04-5/07        University of Pennsylvania Teaching Assistant

                                    Organic Chemistry Lab & Recitation

Education

9/04-6/09        Graduate Student in Organic Chemistry

                                    Ph.D. Awarded June 2009

                              University of Pennsylvania; Philadelphia, PA

9/00-5/04        Bachelor of Arts in Chemistry, summa cum laude

                                    Minor in Cell and Molecular Biology

                                    Albion College; Albion, MI

Research Experience

6/09-8/11        NIH Postdoctoral Research Fellow with Prof. William F. DeGrado & Joel S. Bennett, University of Pennsylvania

Chemical and biochemical methods for deconvoluting the inside-out integrin activation mechanism

9/04-6/09        Dissertation with Prof. Eric Meggers, University of Pennsylvania

                       Thesis Title: Bioactive organometallic complexes: From structure to function

9/00-5/04       Thesis Research with Prof. Andrew N. French, Albion College and Prof. Thomas Wirth, Cardiff University

Towards the synthesis of chiral hypervalent iodine reagents for use in catalysis

Research Funding

12/12-            Royal Society of Chemistry

                      Research Mentor: Nathan Wong: Sigma Xi Grant-in-aid of Research

                      Research Mentor: Lehigh Grants for Experiential Learning in Health

Selected Awards and Honors

--NIH Postdoctoral Fellow, Hematology Training Program, Department of Biochemistry and Biophysics, University of Pennsylvania (2009-2011)

--Graduate Student Teaching Assistant Commendation, Department of Chemistry, University of Pennsylvania (2005)

--David L. Randall Most Outstanding Senior Chemistry Major, Albion College (2004)

--Richard Vitek Outstanding Sophomore/Junior Chemistry Major, Albion College (2003)

--Putnam (CRC) Outstanding Chemistry Freshman, Albion College (2002)

--Phi Beta Kappa, Albion College (2004)

--Sigma Xi, Albion College (2004)

Publications

Streu, C., Meggers, E.  “Ruthenium-induced allyl carbamate cleavage in living cells,” Angew. Chem., Int. Ed. 2006, 45, 5645-8.

*Xie, P., Streu, C., Qin, J., Bregman, H., Pagano, N., Meggers, E., Marmorstein, R. “Crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase,” Biochemistry, 2009, 48, 5187-5198.

*EDITOR’S CHOICE: Science Magazine

Streu, C., Carroll, P. J., Kohli, R. K., Meggers, E.  “Synthesis of cyclopentadienyl ruthenium complexes bearing pendant chelating picolinates through an electrophilic precursor,”  J. Organomet. Chem. 2008, 693, 551-556.

Atilla-Gokcumen, G. E., Pagano, N., Streu, C., Meggers, E. "Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3," ChemBioChem. 2008, 9, 2933-2936.

COVER ARTICLE

Zhu, H., Metcalf, D. G., Streu, C. N., Billings, P. C., DeGrado, W. F., Bennett J. S. “Specificity for Homooligomer versus Heterooligomer Formation in Integrin Transmembrane Helices,” J. Mol. Bio., 2010, 401, 882-891.

Streu, C., Feng, L., Carroll, P. J., Maksimoska, J., Marmorstein, R., Meggers, E. “P-donor Ligand Containing Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors,” Inorg. Chim. Acta, 2011, 377, 34-41.

Shandler, S. J., Korendovych, I. V., Moore, D. T., Smith-Dupont, K. B., Streu, C. N., Litvinov, R. I., Billings P. C., Gai, F., Bennett, J. S., DeGrado, W. F. “Computational design of a -peptide that targets transmembrane helicies,” J. Am. Chem. Soc., 2011, 133, 12378-12381.

Sun, J., Vranic, J., Composto, R. J., Streu, C., Billings, P. C., Bennett, J. S., Weisel, J. W., Litvinov, R. I. “Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles,” Integrative Biology, 2012, 4 (1), 84-92.

Sasmal, P. K., Carregal-Romero, S., Han, A. A., Streu, C. N., Lin, Z., Namikawa, K., Elliott, S. L., Köster, R. W., Parak, W. J., Meggers, E. “Catalytic azide reduction in biological environments,” ChemBioChem, 2012, 13(8), 1116-1120.

Sasmal, P. K., Streu, C. N., Meggers, E.  “Metal Complex Catalysis in Living Biological Systems,” ChemComm., 2013, 49, 1581-1587.

Mentored Research Presentations

 

Hood, J. G., Jespersen, J. M., Streu, C. N. Inhibition of quinone reductase 2 by novel resveratrol analogs, 244th American Chemical Society National Meeting, Philadelphia, PA, August 2012 (poster).

Iorio, P. R., Anzideo, N., Streu, C. N. Progress towards synthesis of a transition metal coordination complex analog of the neocarzinostatin metabolite core, 244th American Chemical Society National Meeting, Philadelphia, PA, August 2012 (poster).

Olexa, J. R., Streu, C. N., Progress toward synthesis of a transition metal coordination complex analog of the neocarzinostatin metabolite core, 245th American Chemical Society National Meeting, New Orleans, LA, April 2013 (poster).

Sharp, E. I., Streu, C. N. Solid phase immobilization of a superoxide dismutase mimic, 245th American Chemical Society National Meeting, New Orleans, LA, April 2013 (poster).

*Anderson, C. C., MacDonald, L. C., Nice, J. B., Berger, B. W., Streu, C. N. Expression and purification of a MORN fusion protein from Pseudomonas aeruginosa, Experimental Biology 2013, Boston, MA, April 2013 (poster).

*Awarded ASBMB-UAN travel grant to EB2013

Selected Research Presentations

Streu, C., The elusive role of kindlin-3 in inside-out signaling, Hematology/Oncology Research Seminar, University of Pennsylvania School of Medicine, May 2010 (talk).

Streu, C.   Assessing the biochemistry of kindlin-3 in human platelets, 52nd Annual Meeting, Special Symposium on the Basic Science of Hemostasis and Thrombosis, Orlando, FL, December 2010 (talk).

Streu, C., Nygren, P., Moore, D., Billings, P., Fong, K., Metcalf, D., Wu, Y., DeGrado, W. F., Bennett, J. S.   Assessing the biochemistry of kindlin-3 in human platelets, 52nd Annual Meeting, Orlando, FL, December 2010 (poster).

Streu, C. Organometallic Kinase Inhibitors: From Structure to Function, Albion College, Albion, MI, October 2009 (invited lecture).

Streu, C., Meggers, E. Organometallic chemistry in living cells, 232nd ACS National Meeting, San Francisco, CA, September 2006 (poster).